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from the 1930s-1960s, and regionally as recently as 2013

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A meta-analysis was performed of three RCTs comprising 10110 patients by RevMan 5.4.1 software to determine varenicline's efficacy compared with bupropion in smoking cessation

We used a public health framework that balanced tensions between utilitarianism, which posits that actions are desirable if they benefit the majority, and liberalism, which maintains above all that individuals have the right to self-determination in health