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The breakthrough "nicotine salts" formula that made the Juul e-cigarette so addictive and ignited the company's explosive market-share growth made Juul especially attractive to teenagers and other new users who otherwise would never have smoked cigarettes, according to interviews with more than a dozen tobacco researchers, pediatricians, and a Reuters review of Juul patents and independent research on nicotine chemistry

As of July 1, 2019, it is illegal for anyone under the age of 21 to purchase, use or possess any tobacco, nicotine vapor or alternative tobacco product in Virginia

Young adults had increased odds of selecting the packaging with the flavor descriptor as attracting their attention (OR: 1.657, CI: 1.223-2.245), having the better taste (OR: 2.0065, CI: 1.519-2.806), to want to be seen using (OR: 2.355, CI: 1.1.664-3.333) and appealing to people their age (OR: 2.340, CI: 1.714-3.194) than older adults

Nrf2 - nuclear factor erythroid 2 like 2