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Tirzepatide, having received FDA approval, has a more defined safety record, though patients should be monitored for potential risks such as pancreatitis or thyroid tumors, which have been concerns with GLP-1 receptor agonists in general

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Inhibition of Glucagon Secretion by GLP-1 Agonists and DPP4 Inhibitors. JCMD 2 (2011): 7-13