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Acetaminophen-associated overdoses account for approximately 56,000 emergency department visits, 26,000 hospitalizations, and over 450 deaths annually

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Ethics approval The experimental protocol followed the national animal rights regulation (Law 11.794/2008) and the Guide for the Care and Use of Laboratory Animals (National Institutes of Health, 8th edition, revised 2011) and Directive 2010/63/EU

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