In recent years, studies on SZ bodily fluids have consistently reported increased numbers of TLR4-positive monocytes and elevated TLR4 expression in the peripheral blood of schizophrenia patients (149, 153155), suggesting that TLR4 upregulation is a key factor in the immunopathological process of schizophrenia
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Mice with a homozygous deletion of the Rag-2 alleles completely lack NK-like T, T and B cells and have increased incidence and growth of spontaneous tumors and chemically induced cancer lesions (77)
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