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Preclinical analysis
As one of the stress response mechanisms maintaining cellular homeostasis, moderate ISR selectively targets the mitochondrial complex I assembly factor NDUFAF2 for translational inhibition and reduces the production of ROS related to complex I [176]
The ALDH1 protein is a cytosolic enzyme while the ALDH2 proteins reside in the mitochondria
1st Optimal providers can only prescribe medications after establishing a proper doctor-patient relationship through formal consultation, medical history review, and appropriate laboratory testing
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