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The duration of action is dose-dependent: 12h for doses of 0.2U/kg and 20h for doses of 0.4U/kg

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By integrating nanoparticles, chemotherapeutics, or oxygen-releasing agents within the hydrogel matrix, these systems actively modulate the tumor microenvironment, overcoming key barriers such as hypoxia, high interstitial pressure, and intrinsic radioresistance that often limit conventional therapy [43]