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Description

Pumera, M., Snchez, S., Ichinose, I., & Tang, J

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For CJC-1295 specifically, the maleimide group in the DAC variant is additionally susceptible to hydrolysis under certain conditions, which can impair albumin-binding capacity and alter pharmacokinetics in study models

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In particular, USP22 raised GSH content and reduced the occurrence of ferroptosis in cardiomyocytes by activating the Sirt1-p53/SLC7A11 axis [252]

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