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Fortunately, many GLP-1 receptor agonists have demonstrated cardiovascular benefits rather than risks in dedicated outcome trials

Local IGF-I/IGF-IR signaling promotes the growth, survival and differentiation of chondrocytes and osteoblasts, directly and indirectly, by altering other autocrine/paracrine signaling pathways in cartilage and bone, and by enhancing interactions among these skeletal cells through hormonal and physical means

J Pharmacol Exp Ther