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Key Points Your body takes about 5 weeks to completely eliminate semaglutide after your last dose, with effects gradually wearing off during this period Clinical studies show people typically regain two-thirds of their lost weight when they stop taking semaglutide medication Work with your healthcare provider to gradually reduce doses instead of an abrupt stop A nutritious diet and exercise can help you manage semaglutide withdrawal symptoms Your body adapts to semaglutide over time, creating changes that don't simply reverse when you stop

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It can also significantly slow your heart rate

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If you'd prefer FDA-approved tirzepatide for weight loss, see Zepbound KwikPen same active ingredient, on-label for chronic weight management