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Chronic or repeated HPA axis stimulation raises legitimate concerns, as sustained cortisol elevation is associated with insulin resistance, altered body composition, bone loss, immune modulation, and cardiovascular effects

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To establish bioequivalence, the estimated treatment ratio should be fully contained within 0.80001.2500 and the 95% upper CI for ( T R ) 2 S 2 WR , based on Howes approximation, should be 0