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By examining the gut-liver axis as the central integrative pathway, this review explores how microbial dysbiosis mechanistically contributes to MASLD initiation and progression, and how hepatic metabolic dysfunction reciprocally alters gut microbiome composition

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Significance Statement Dementia is a slowly progressing, chronic, and usually irreversible decline in cognitive function

These findings have generated considerable scientific interest, though it is important to note that retatrutide remains under investigation and has not yet received regulatory approval for routine clinical use