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The appearance of mild-yellowish, mosaic symptoms was associated with a dramatic, 20-fold induction of defense-related genes like PR-1, chitinase and GST (Niehl et al., 2006)

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Typically, their adrenal glands produce too little endogenous cortisol

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These elevations are consistent with their accumulation in fibrotic lungs and their potential involvement in mTORC1-driven fibroblast activation [133, 134]