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Risks of TMAO In 1984 Rebouche et al

Oral formulations of triple-agonist peptides are in very early development and are not commercially available in any reliable form

Chikani, V., & Ho, K

The non-enzymatic mitochondrial protein hyperacetylation induced by the increased availability of mitochondrial acetyl-CoA avoids the risk associated with mitochondria overfeeding, restraining the activity of the respiratory complex I and modulating CACT activity

This is fundamentally different from, say, the use of very high, unregulated doses of exogenous HGH, which can push IGF-1 levels far beyond the upper limits of the normal range