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The resulting acetonitrile solution was slowly cooled to give 2,2-(propane-2,2-diylbis(sulfanediyl))diacetic acid

Circulation 117:915922 Dokun AO, Chen L, Lanjewar SS, Lye RJ, Annex BH (2014) Glycaemic control improves perfusion recovery and VEGFR2 protein expression in diabetic mice following experimental PAD

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Nevertheless, although a specific action of homocysteine seems to occur at low concentrations, experimental trials have been conducted only with homocysteine administration, which would reflect a severe hyperhomocysteinemia rather than a more physiologic moderate elevation of circulating homocysteine, and clinical observations have only come from homocystinuric patients with severe hyperhomocysteinemia