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and all other states

For instance, iron overload can enhance chondrocyte catabolism through overactivated NLRP3 inflammasomes, promoting MMP expression and exacerbating cartilage degeneration ( Recent studies have established a close relationship between ferroptosis and ECM degradation (Wilkinson et al., 2019)

When the adrenal glands are overworked for extended periods, the cortisol they produce progressively reduces

Additionally, any unexplained weight loss exceeding 12 kg per week should be discussed with a clinician to rule out inadequate nutrition or other underlying concerns

Therefore, a low-calorie diet may not provide sufficient vitamins and minerals, and they might need to take supplements to meet their daily needs