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These changes compromise the biomechanical function of the meniscus and reduce its capacity to distribute load, thereby increasing stress on adjacent cartilage and subchondral bone

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Treating the metabolic conditions becomes part of treating the osteoarthritis. Research has shown that patients with type 2 diabetes are more likely to have severe osteoarthritis as well as a higher likelihood of needing revision surgeries after knee replacements

other analyses (including Journal of Alzheimers Disease and JAMA Neurology) similarly report reduced incident dementia with GLP-1 Receptor Agonists as a class