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As rigorous studies begin to clarify mechanism, dose, timing, and patient selection, GLP-1 agents may one day play a supportive, targeted role for a specific subset of patients

Due to the complex pathogenesis of the disease, which involves autoimmunity, genetics, inflammation and oxidative stress in the bodys tissues, the current drug therapy generally targets a single molecule, and effective and efficient drugs involving multiple levels and targets are lacking

Similarly, the absence of TMEM16A in AT2 cells can mitigate S-ALI by reducing ERS-related ferroptosis during ALI (Xu et al., 2023

16 However, immune aging exacerbates disease progression in patients with COPD