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Primary Endpoint Disease-free survival (DFS) Secondary Endpoints: Loco-regional failure-free survival (LRFS), distant metastasis-free survival (DMFS), overall survival (OS), pathological complete response (pCR), R0 resection rate, toxicity, and post-surgical complications Background Locally advanced rectal cancer (LARC) with threatened or involved circumferential resection margins (CRM) represents a high-risk group for recurrence and poor outcomes
Contraindications and Precautions Do not use if : You are pregnant, nursing, or trying to conceive You have uncontrolled hypertension You are hypersensitive to peptide-based therapies You have a history of cardiovascular events unless medically cleared Use caution if : Youre on concurrent medications affecting blood pressure or libido You have known dopamine dysregulation conditions You are using other sexual function medications (e.g., PDE5 inhibitors) Storage and Handling Store lyophilized powder at 28C (3646F) Once reconstituted, refrigerate and use within 30 days Use sterile technique for mixing and withdrawal Protect from direct light and avoid contamination Why Choose PT-141
Int J Mol Sci 2020;21
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