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In WT mice, systemic inhibition of DPP-4 activity, which inhibited plasma DPP-4 activity by about 90%, improved lipid tolerance and increased plasma active GLP-1 levels by approximately 4.5-fold in HFD-fed mice (Figure 5)

In healthy humans, CCK released from EECs enters the circulation and peaks in concentration from 6 to 15 pmol/L at ~90120 min postprandial depending on fat content and meal form 157,158

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Este hallazgo es til para definir un posible diagnstico, al excluir otras causas de melanoniquia como hematomas y afecciones micticas y al permitir planificar el mejor sitio para la toma de la biopsia en la matriz