Long-term studies specifically focused on women with established osteoporotic risk are still needed
Compound Receptors Peak trial weight loss Lean mass as share of loss Semaglutide (Ozempic/Wegovy) GLP-1 ~14.9% (STEP-1, 68 wk) ~39% Tirzepatide (Mounjaro/Zepbound) GLP-1 + GIP ~20.9% (SURMOUNT-1, 72 wk) ~25-40% Retatrutide GLP-1 + GIP + GCGR ~24.2% (Phase 2, 48 wk) Comparable class range Best for understanding the takeaway: the percentage of loss that is lean mass is roughly constant across the class
Tirzepatide may be favored for those with complex diabetes or insulin resistance, while semaglutide is also effective and has a longer safety record in diabetes management
Providers consider factors such as injury location, severity, duration of symptoms, and whether other therapies such as physical rehabilitation or lifestyle modifications are already in place
How To Pass Through Airport Security With Tirzepatide While Traveling Travelers may carry medications in liquid or injectable form exceeding the standard TSA liquid limit (3.4 ounces or 100 mL)