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These observations, while not formal clinical trials for acne, highlight its potential for broader skin health benefits

While some of these drugs are actually used on-label to treat the symptom they are registered for (e.g., infertility, acne), we consider them here as repurposed since they are not a PCOS treatment and do not address the underlying cause of the condition

Animal studies have shown that in a rat model of TLE, elevated hippocampal IL-1 levels lead to HPA axis dysfunction and impaired hippocampal-raphe 5-HT pathway function, resulting in depressive-like behaviors (Mazarati et al., 2010)

Outside the EU, it is widely registered for use in countries such as Russia, Ukraine, Georgia, Kazakhstan, Azerbaijan, Belarus, Uzbekistan, and Moldova, but not in the United States

Tissue remodelling pathway studies