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These findings argue against routine add-on use in unselected good-prognosis populations and highlight the importance of patient selection and pre-test probability of WOI displacement [5, 291]

Patients with certain conditionsincluding asthma (where glutathione may interact with bronchial function), kidney disease, or those taking chemotherapyshould only use glutathione under direct provider supervision

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For example, STI1, a highly selective small-molecule SQOR inhibitor developed by 2 S catabolism raises endogenous H 2 S levels, thereby activating cardioprotective signaling pathways such as protein sulfhydration