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Free cobalamin is released from the intestinal enterocytes to the blood via TC-Cbl interaction with a basolateral membrane transporter that is a member of the ATP-binding cassette family of transporters, specifically the ABCC1 transporter

Following study selection, data extraction was performed independently by RM and RC using a structured extraction form in Microsoft Excel, with all entries cross-checked for accuracy

In diet-induced obese (DIO) mouse models, NNMT inhibition with 5-Amino-1MQ was associated with reduced white adipose tissue mass without affecting food intake, suggesting changes in energy expenditure rather than appetite suppression