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Impact of DPP4 Inhibition on Pancreatic Islets Accumulating in vitro and pre-clinical data show that DPP4 inhibition has beneficial effects on T2DM induced -cell dysfunction and apoptosis

These pharmacokinetic advantages stem directly from orforglipron's non-peptide nature: as a small molecule, it is inherently resistant to proteolytic degradation in the gastrointestinal tract and does not require the pH-dependent, site-specific absorption mechanisms that constrain peptide-based oral formulations (see our peptide research hub)