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The main effect in using it for skin whiteningis most likely a side effect of making the skin lighter as it protects the cells from free radicals responsible for skin pigmentation and blemishes

[Nitric oxide and neurological animal models.] US Food and Drug Administration

Nevertheless, Endocan cannot currently be used as a biomarker for diagnosis or prognosis, and further research is needed to verify its value

Figure 6 From our RNAseq analysis, we noted that many of the upregulated genes in the glutathione biosynthesis pathway (including Gclc and Gclm ) are canonical targets of the transcription factor NRF2 (53, 54)

Jimi E, Aoki K, Saito H, DAcquisto F, May MJ, Nakamura I, et al