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Glucagon-like peptide-1 (GLP-1) is a glucoregulatory hormone synthetized in the intestines and the brain, involved in the maintenance of energy homeostasis mainly by stimulating insulin secretion and regulation of appetite

[10] [11] [12] In the TMD domain a fulcrum of polar residues regulates the biased signaling of the receptor [10] while the transmembrane helical boundaries [13] and extracellular surface are a trigger for biased agonism