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However, the clinical decision about how to stop tirzepatide extends beyond simple pharmacology

A related concern is the body composition consequence of rebound: GLP-1 RA-induced weight loss includes a proportional loss of fat-free mass, and weight regained after discontinuation returns disproportionately as fat a sarcopenic recomposition pattern that is physiologically expected during weight cycling and is only now being formally quantified in the GLP-1 RA context (Tinsley & Heymsfield, 2024)

Strong average weight-loss outcomes in major obesity trials

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Following reconstitution, refrigerated storage and prompt use are recommended