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Humidity is equally important

145, 146 PGE 2 is increased in the airways of smokers and COPD patients in whom it exerts not only beneficial effects, through bronchodilatation and immunosuppression, but also negative effects by enhancing mucus secretion

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139 Although VEGF release upon smoking is mainly aimed at maintaining tissue homeostasis and alveolar structure, 90 its aberrant expression in larger airways might alternatively contribute to allergen sensitization