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The Nose-Hoover thermostat was used to maintain the simulation temperature at 300 K, and the Parrinello-Rahman barostat was employed to control the pressure at 1 bar under semi-isotropic conditions

Im just saying this so that we dont write off these other benefits aside from increased weight loss as insignificant

Genistein, a polyphenolic nonsteroidal compound derived from plants, is among the most extensively studied phytoestrogens, exhibiting estrogen-like bioactivity without significant toxic effects during prolonged use (183)