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Multiple organisms are involved in the gut microbial production of TMA from l-carnitine

Additionally, it has been shown that the 20-year survival rate free of liver transplant for children with NAFLD was about 80% compared to 99% in the reference population [283]

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Therefore, both temporal and spatial considerations of IGF-1R modulation will need to be considered in future trials with these drugs in order to clearly define the benefits and potential risks associated with this treatment, and guide development of strategies that allow for safe and effective long-term human use