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This early appetite suppression occurs because GLP-1 receptors in the hypothalamus are activated, reducing hunger signals and increasing feelings of fullness

Under the UK Patient Group Directions for Wegovy and Mounjaro , continued treatment for weight management is only permitted while: BMI remains at or above 22 kg/m This applies: To maintenance treatment To all ethnicities Regardless of dose strength Once BMI falls below 22 kg/m , GLP-1 medication must usually be stopped

Drink at a lower temperature If you are drinking it hot don't use boiling water, ideally 70-75 degrees Celsius or try a cold preparation like Terer

PARG inhibitor (PARGi) treatment was used as a positive control

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