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In this trial, 3,183 adult patients with inadequately controlled type 2 diabetes mellitus and atherosclerotic CV disease were randomized to semaglutide tablets 14 mg orally once daily or placebo for a median observation time of 16 months

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2021;36:e112

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Weight loss during this period is typically 2 to 4 pounds, primarily from reduced caloric intake and initial fluid shifts

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Retatrutide has received attention for strong clinical trial results, but it is not currently FDA-approved

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