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Adding CJC/Ipa brings injection-site reactions and mild water retention

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In patients with diabetes and albuminuria, the HRs for MACE, HHF, and CKD progression with triple combination therapy were estimated to be 0.65 (95% CI 0.550.76), 0.45 (95% CI 0.340.58), and 0.42 (95% CI 0.310.56), respectively, compared with those for conventional therapy alone (renin-angiotensin system inhibitors and classical risk factor management)

This positioning reflects awareness of the mechanistic differences between probiotic support and pharmaceutical intervention

Open research questions Important unanswered questions remain: the longterm cardiovascular implications of supplementrelated TMAO rises, optimal doseresponse in different age groups and sexes, and whether specific probiotics or conutrients can reduce gut conversion of carnitine to TMAO while preserving benefits