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One suggested practice to managing GI AEs is the Three Es method, which comprises 1) education and explanation, 2) escalation to an appropriate dose, and 3) effective management of GI AEs

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The diagnosis of Melanotic Macules of Oral Mucosa may involve the following procedures: The diagnosis is usually made by a complete physical (oral) examination and evaluation of medical history and family history Skin biopsy: A skin biopsy is performed and sent to a laboratory for a pathological examination, who examines the biopsy under a microscope

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