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a continued downward slope suggests either the dose wasnt maximal, adherence held, or the biology stayed responsive

Recent studies have revealed that neuronal Glp1r activation in mice is required for the reduction in systemic inflammation through a unique set of neurotransmitter systems 32 and that brainstem neurons can sense peripheral cytokines and exert control over systemic immune responses 33 , suggesting complex neuro-immune communication circuits

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Biochim Biophys Acta (BBA) - Bioenergetics

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