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Aminochrome has been proposed to play an essential role in the degeneration of dopaminergic neurons containing neuromelanin by inducing mitochondrial dysfunction, oxidative stress, the formation of neurotoxic -synuclein protofibrils, and impaired protein degradation

Additionally, novel self-sufficient DNAzyme nanosponges with polymerized DNAzyme-substrate scaffolds and pH-reactive ZnO nanoparticles were reported