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Immunohistochemistry verified that estrogen signaling inhibits intestinal inflammation

Studies have demonstrated that induction of HO-1 expression in macrophages yields amplified antioxidant efficacy and mitigates the inflammatory aspect of atherosclerotic lesions

SLC22A5 is central

Crucially, the GSH/Glutaredoxin 1 system maintains the reduced state of cysteine residues within the copper-binding motifs of the transporters ATP7A and ATP7B, which is essential for their copper-transport activity [108]