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9 However, there are certain limitations of intranasal administration, such as decreased therapeutic efficacy as a result of the short nasal residence time of the administered drug due to the rapid mucociliary clearance mechanism

A study in the Journal of Clinical Biochemistry says, Vitamin B12 deficiency can cause big problems with nerves and blood. Vitamin B12 is key for making DNA, fatty acids, and energy. Source: Journal of Clinical Biochemistry Common Signs of Deficiency A Vitamin B12 shortage can show in many ways, like: Fatigue and weakness Numbness or tingling in hands and feet Difficulty walking Mood changes, such as depression Spotting these signs early is key for quick action

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At 3.33 mg/mL: 10 units = 0.333 mg At 5 mg/mL: 10 units = 0.5 mg At 2.5 mg/mL: 10 units = 0.25 mg At 2 mg/mL: 10 units = 0.2 mg Same number of units

Although our results were promising in reducing anxiety scores after vitamin B12 treatment, the patients depression scores were not diminished post-treatment in our patients