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The prevailing scientific consensus assumed these outcomes stemmed from the drugs crossing the blood-brain barrier to hit central nervous system receptors
* First-Submission Approval reflects approximate rates that initial PA requests are approved (data from industry surveys ( [3] ) ( [4] ))
This does not exclude the possibility of skin sensitivity occurring in a subset of patients, particularly as Phase 3 trials enrol larger and more diverse populations
Individuals with pre-existing diabetic retinopathy, long diabetes duration (typically over 10 years), poor prior glycaemic control, and those experiencing rapid HbA1c reductions face the highest risk
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