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In naturally aged mice, FOXO4-DRI improved the testicular microenvironment and alleviated age-related testosterone secretion insufficiency with decreased p53, p21, and p16 protein levels in treated testes compared to aged controls

To view a copy of this licence, visit About this article Cite this article Zhu, X., Fowler, M.J., Wells, Q.S

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This affects the upstream metabolites in the methionine and transsulfuration pathways because GSSG inhibits the enzymes MAT-I and MAT-III [57, 58]