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Some hypothetical explanations for the weaker anti-obesity response for both GLP-1 RAs in people with diabetes include the background medications that promote weight gain, the fear of hypoglycaemia inherently related to the treatment of diabetes, a decrease in glycosuria and subsequently less weight loss in diabetics, an altered microbiota in patients with obesity and diabetes and a genetic background that predispose to weight gain in patients with diabetes

The other treatment I think will be a big trend this year is HIFU (high intensity focused ultrasound)

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7 It may be a treatment option for the future

doi: 10.1055/s-0031-1297042