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The dual mechanism also appears to provide better preservation of lean mass during weight loss, though head-to-head comparison data is still limited

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Arch Intern Med 159:21772183 Roglic G, World Health Organization (2016) Global report on diabetes

Affordable options are also emerging: platforms like Oana Health provide telehealth access to GLP-1 medications, including semaglutide and tirzepatide, with oral versions and GLP-1/metformin combinations available for $199 per month