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it showed that risk rises with long-term high Lp(a).[ref] Waist-to-hip ratio as a modifying factor for atherosclerosis: A 2025 study involving ~800 people with Lp(a) over 50 mg/dL showed that those with a larger waist-to-hip ratio (more belly fat) were at a much higher risk of atherosclerosis

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These medications should be discontinued at least two months before attempting pregnancy due to their effects on fetal development

On the other hand, GLP-1 RA can reduce epicardial fat and semaglutide 2.4 mg have shown to improve physical function and symptoms in people with HFpEF [93]