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An Updated Review of the Literature. Frontiers in Physiology

HFpEF can worsen CKD due to elevated central venous pressure, which leads to congestive nephropathy

This is consistent with the phase 2b clinical trial, where the total 12-week result was 2.8kg (6.2 lbs) additional fat loss versus placebo (clinical trial data)

Curr Opin Psychiatry 30(6):452457 Rodan S-C et al (2023) Pharmacotherapy, alternative and adjunctive therapies for eating disorders: findings from a rapid review