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3.6 Potential Microbiome Changes GLP-1 receptor agonists alter: Gastric motility Transit time Food intake patterns Emerging research suggests that weight loss and altered dietary intake may influence gut microbiota composition. At present, there is insufficient evidence to conclude that GLP-1 drugs independently cause clinically significant microbiome-mediated nutrient depletion

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Ta A, Caudle AS, Hayes-Jordan A, Lai S, Mehran RJ, Moon BS, Prabhu SS, Reece G, Schmeler KM, Skibber JM, Ward JF, Chemaly RF, Anderson JJ, Segal C, Ca P, Fleming JB, Swisher SG , Levenback CF