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In addition, gut microbiota and gut microbiome-derived metabolite, indole-3-acetic acid, were also reported to contribute to the efficacy of SFN in improving HFD-induced hepatic steatosis along with Aryl hydrocarbon receptor (AHR)/SREBP1c pathway-mediated lipid metabolism (Xu et al., 2021)

10.1146/annurev-immunol-103019-085803 179 SahadevanR.BinoyA.ShajanI.SadhukhanS

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But his boss, then-Chief Scientific Officer Mads Krogsgaard Thomsen, had a different vision one that would ultimately reshape how the world treats obesity and diabetes