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Experimental NNMT inhibition with compounds such as 5-Amino-1MQ has been reported to correlate with: Reduced fat cell size and changes in fat mass in diet-induced models Shifts in metabolic efficiency and energy utilization Altered expression of glucose transporters (including GLUT4) in skeletal muscle and fat tissue Some studies have observed notable changes in body mass and adipose tissue over relatively short experimental periods without modifications in food intake

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The rapid increase in muscle mass can outpace tendon and ligament adaptation , increasing the risk of soft tissue injuries

Pevec et al., 2010) and worsening, as well as immunosuppression (Sikiric et al., 2003)

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