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The expression level of pyruvate dehydrogenase (encoding by aceE ), which catalyzes the reaction from pyruvate to the formation of acetyl-CoA, was only 0.13-fold in MG12345

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While These figures represent intake inadequacy (dietary intake below the Estimated Average Requirement from food alone), not biochemical deficiency, the takeaway is that nutritional gaps are very common, and I see them in nearly every patient I care for, including women in their 20s and 30s and professional athletes, and most commonly, in women 40 and older

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