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Principal componentbased epigenetic clocks (PCHorvath1, PCHorvath2, PCHannum, PCPhenoAge, PCGrimAge) were calculated using the PC-Clocks repository ( Non-PC Horvath, Hannum, and DNAmPhenoAge clocks were calculated using the methyAge function in the ENmix R package (v1.44.3)

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JAMA Network Open, 7 (5), e2412437

This platform demonstrated enhanced oral insulin bioavailability, achieving superior glycemic control with dual hypoglycemic and insulin-sensitizing effects in diabetic murine models compared to conventional intravenous administration